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KMID : 0670820130180040111
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Korean Journal of Medical Mycology
2013 Volume.18 No. 4 p.111 ~ p.116
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Primary Cutaneous Cryptococcosis in a Patient with Pulmonary Tuberculosis
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Kim Tae-Wook
Park Sung-Min
Mun Je-Ho
Song Margaret
Kim Hoon-Soo
Kim Byung-Soo
Kim Moon-Bum
Ko Hyun-Chang
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Abstract
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Cutaneous manifestation due to Cryptococcus neoformans is mostly reported in cases of the secondary findings to hematogenous dissemination while the primary cutaneous cryptococcosis (PCC) is a very rare. PCC usually occurs in immunocompromised hosts such as AIDS, hematopoietic malignancies, transplant recipients, and chronic corticosteroid users. Primary cryptococcosis and tuberculosis co-infection has been rarely reported in Korean literature. We report a case of PCC in a 22-year-old male with pulmonary tuberculosis, who had asymptomatic erythematous plaque and papules on the right cheek for 3 months. Histopathological examination showed numerous encapsulated round spores in the dermis and the organism was identified as Cryptococcus neoformans on fungal culture. The lesion was successfully treated with oral fluconazole for 6 months, and pulmonary tuberculosis was resolved after anti-tuberculosis therapy for 9 months.
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KEYWORD
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Primary cutaneous cryptococcosis, Pulmonary tuberculosis, Co-infection
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